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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in adults with a body mass index (BMI) of more than 27, provided they also have problems with weight-related health issues such as Tupe2 diabestes, high cholesterol and/or hypertension (blood pressure).Contrave is often a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder and as an aid to stop smoking treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle which includes a reduced-calorie dieting and exercise, Contrave provides another treatment option for chronic weight-loss for people who are obese or are overweight and also have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that contains a reduced- calorie diet and regular exercising. Results from a medical trial that enrolled patients without diabetes demonstrated that patients had a normal weight loss of four.1% rather than participants have been given placebos) within a 12- month period, while an outside study involving patients with diabetes type 2 symptoms had a normal weight loss of 2% over treatment with placebo at 12 months.

Using two separate drugs to lose weight can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight-loss and the people that go through it you ought to err along the side of caution and allow FDA do its job and demand some study be done so the public is aware of the side effects and hazards of the medications before we bring them. Keep in mind that drug companies have been in business to generate money and that they would say almost anything to keep people on their own medications.

Researchers found that participants using this drug for the year, dropped excess weight within four weeks and have kept the extra weight off throughout the 56 weeks from the study. Contrave is a combination in the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs that are made up of many active ingredient, that might make them more effective and safer.

Combo-pilling is the newest fad or even better the newest to come under scrutiny and so it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is becoming popular will be the fact that since right now there aren't long term prescription weight loss supplements that have been approved by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures can be a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug could also raise blood pressure and pulse rate, and really should not be used in people with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must 't be used in patients with uncontrolled high hypertension, along with by you are not heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients which has a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients towards the increased likelihood of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.


Acamprosate also works to eliminate the need to drink by eliminating the the cravings for having a drink. The major difference between Naltrexone and Acamprosate is always that Acamprosate isn't yet available in the United States. While it has been widely studied in Europe the exact chemical believe that it works is still unknown. It is believed that it inhibits receptors inside the brain which process glutamate, which essentially alters the way in which ones body reacts to alcohol intake. Several of the European research shows a lot of promise with Acamprosate for the reason that some of the patients had a practically double success rate for staying sober.